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Terpenoidal constituents of Eucalyptus loxophleba ssp. lissophloia

Sidana, Jasmeen; Singh, Sukhvinder; Arora, Sunil Kumar; Foley, William; Singh, Inder Pal

Description

Context: Eucalyptus has been a source of a number of biologically active compounds. The anti-leishmanial activity of terpenoids from Eucalyptus loxophleba (Benth.) ssp. lissophloia (Myrtaceae) has not yet been investigated. Objective: Isolation of the terpenoidal constituents for evaluation of in vitro anti-leishmanial activity against the Leishmania donovani (Dd8 strain) promastigotes. Materials and methods: The chloroform-methanol (8:2) extract of dried leaves of Eucalyptus loxophleba was...[Show more]

dc.contributor.authorSidana, Jasmeen
dc.contributor.authorSingh, Sukhvinder
dc.contributor.authorArora, Sunil Kumar
dc.contributor.authorFoley, William
dc.contributor.authorSingh, Inder Pal
dc.date.accessioned2015-12-10T23:13:41Z
dc.identifier.issn1388-0209
dc.identifier.urihttp://hdl.handle.net/1885/64534
dc.description.abstractContext: Eucalyptus has been a source of a number of biologically active compounds. The anti-leishmanial activity of terpenoids from Eucalyptus loxophleba (Benth.) ssp. lissophloia (Myrtaceae) has not yet been investigated. Objective: Isolation of the terpenoidal constituents for evaluation of in vitro anti-leishmanial activity against the Leishmania donovani (Dd8 strain) promastigotes. Materials and methods: The chloroform-methanol (8:2) extract of dried leaves of Eucalyptus loxophleba was used to isolate terpenoidal constituents employing solvent partitioning, column chromatography and preparative high performance liquid chromatography and characterized from spectral data. The anti-leishmanial activity of the isolated compounds was tested in vitro using an Alamar blue assay against a culture of L. donovani (Dd8 strain) promastigotes. Results: Two new naturally occurring triterpenes, named loxanic acid and 3-acetyl loxanic acid together with four known ursane triterpenoids and one bis-monoterpene glycoside, cuniloside B isolated from the leaves showed anti-leishmanial activity (IC50 133 to 235 μM) against the promastigotes of the tested strain. Conclusion: The terpenes isolated from the leaves of E. loxophleba showed moderate anti-leishmanial activity.
dc.publisherInforma Healthcare
dc.rightsAuthor/s retain copyright
dc.sourcePharmaceutical Biology
dc.subjectKeywords: 3 acetyl loxanic acid; Alamar blue; antileishmanial agent; chloroform; cuniloside B; dye; Eucalyptus loxophleba extract; loxanic acid; methanol; miltefosine; plant extract; robustanic acid; terpenoid derivative; unclassified drug; ursane triterpenoid; urs anti-leishmanial; terpenoid glycoside; Triterpenoid; ursane
dc.titleTerpenoidal constituents of Eucalyptus loxophleba ssp. lissophloia
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume50
dc.date.issued2012
local.identifier.absfor060799 - Plant Biology not elsewhere classified
local.identifier.absfor030502 - Natural Products Chemistry
local.identifier.ariespublicationf5625xPUB956
local.type.statusPublished Version
local.contributor.affiliationSidana, Jasmeen, National Institute of Pharmaceutical Education and Research (NIPER)
local.contributor.affiliationSingh, Sukhvinder, Post Graduate Institute of Medical Education and Research
local.contributor.affiliationArora, Sunil Kumar, Post Graduate Institute of Medical Education and Research
local.contributor.affiliationFoley, William, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSingh, Inder Pal, National Institute of Pharmaceutical Education and Research (NIPER)
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage823
local.bibliographicCitation.lastpage827
local.identifier.doi10.3109/13880209.2011.636058
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2016-02-24T09:45:45Z
local.identifier.scopusID2-s2.0-84862015341
local.identifier.thomsonID000304914800004
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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