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Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

Ioannou, George; Van Rooyen, Derrick; Savard, Christopher; Haigh, W. Geoffrey; Yeh, Matthew; Teoh, Narcissus; Farrell, Geoffrey


Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs). Obese, diabetic Alms1 mutant ( foz/foz ) mice were a fed high-fat (23%) diet containing 0.2% cholesterol for 16 weeks and then assigned to four intervention groups for 8 weeks: a ) vehicle control, b ) ezetimibe (5 mg/kg/day), c ) atorvastatin (20 mg/kg/day), or d ) ezetimibe and atorvastatin....[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Lipid Research
DOI: 10.1194/jlr.M053785


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