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Predicting channel function from channel structure using Brownian dynamics simulations

Chung, Shin-Ho; Kuyucak, Serdar

Description

1. The transport process of ions across the potassium channel is studied using computer simulations. The shape of the model channel corresponds closely to that deduced from crystallography. 2. We first give an intuitive account of how the motion of ions experiencing an applied electric force and interacting with a dielectric boundary and charge residues on the channel wall can be simulated accurately by using a powerful supercomputer. 3. We then show how some of the salient features of ion...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/64354
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1046/j.1440-1681.2001.03408.x

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