Ellis, Nadia M J; Kurahara, David K; Vohra, Harpreet; Mascaro-Blanco, Adita; Erdam, Guliz; Adderson, Elisabeth E; Veasy, L George; Stoner, Julie A; Tam, Elizabeth; Hill, Harry; Yamaga, Karen
Although immune responses against group A streptococci and the heart have been correlated with antibodies and T cell responses against cardiac myosin, there is no unifying hypothesis about carditis caused globally by many different serotypes. Our study identified disease-specific epitopes of human cardiac myosin in the development of rheumatic carditis in humans. We found that immune responses to cardiac myosin were similar in rheumatic carditis among a small sample of worldwide populations, in...[Show more]
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