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Priming the immune system for heart disease: A perspective on group a streptococci

Ellis, Nadia M J; Kurahara, David K; Vohra, Harpreet; Mascaro-Blanco, Adita; Erdam, Guliz; Adderson, Elisabeth E; Veasy, L George; Stoner, Julie A; Tam, Elizabeth; Hill, Harry; Yamaga, Karen

Description

Although immune responses against group A streptococci and the heart have been correlated with antibodies and T cell responses against cardiac myosin, there is no unifying hypothesis about carditis caused globally by many different serotypes. Our study identified disease-specific epitopes of human cardiac myosin in the development of rheumatic carditis in humans. We found that immune responses to cardiac myosin were similar in rheumatic carditis among a small sample of worldwide populations, in...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/64202
Source: Journal of Infectious Diseases
DOI: 10.1086/656214

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