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Genetic repositories for the study of major psychiatric conditions: What do we know about ethnic minorities' genetic vulnerability

Oquendo, M.A.; Canino, G.; Lehner, T; Licinio, Julio

Description

In spite of considerable efforts, no genes of major effect have been found across an entire diagnostic category in psychiatry. Possible reasons for this may include difficulties in defining the phenotype, the complex relationship between genotype and gene expression and population stratification. This last problem has often been managed by restricting genetic sampling to only one ethnic group. An unintended consequence of using this strategy is that the major repositories of genetic material...[Show more]

dc.contributor.authorOquendo, M.A.
dc.contributor.authorCanino, G.
dc.contributor.authorLehner, T
dc.contributor.authorLicinio, Julio
dc.date.accessioned2015-12-10T23:12:44Z
dc.identifier.issn1359-4184
dc.identifier.urihttp://hdl.handle.net/1885/64110
dc.description.abstractIn spite of considerable efforts, no genes of major effect have been found across an entire diagnostic category in psychiatry. Possible reasons for this may include difficulties in defining the phenotype, the complex relationship between genotype and gene expression and population stratification. This last problem has often been managed by restricting genetic sampling to only one ethnic group. An unintended consequence of using this strategy is that the major repositories of genetic material for the study of psychiatric conditions in the United States suffer from a paucity of genetic samples from non-Caucasian groups. Thus, these groups are being relatively understudied in terms of the genetic antecedents to psychiatric disease. The authors provide solutions including the need to augment the representation of African-American, Latino and Asian-Americans among research participants; a more nuanced approach to identify ancestry; and the development of analytic and genetic strategies to handle the issue of ethnic heterogeneity in samples.
dc.publisherNature Publishing Group
dc.sourceMolecular Psychiatry
dc.subjectKeywords: African American; Asian American; ethnic group; gene expression; genetic analysis; genetic heterogeneity; genetic susceptibility; genotype; Hispanic; human; mental disease; phenotype; priority journal; race difference; review; Ethnic Groups; Genetic Heter diversity; DNA; race
dc.titleGenetic repositories for the study of major psychiatric conditions: What do we know about ethnic minorities' genetic vulnerability
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume15
dc.date.issued2010
local.identifier.absfor060411 - Population, Ecological and Evolutionary Genetics
local.identifier.ariespublicationf2965xPUB889
local.type.statusPublished Version
local.contributor.affiliationOquendo, M.A., Columbia University
local.contributor.affiliationCanino, G., University of Puerto Rico
local.contributor.affiliationLehner, T, National Institute of Mental Health
local.contributor.affiliationLicinio, Julio, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue10
local.bibliographicCitation.startpage970
local.bibliographicCitation.lastpage975
local.identifier.doi10.1038/mp.2010.11
dc.date.updated2016-02-24T08:33:42Z
local.identifier.scopusID2-s2.0-77957147510
CollectionsANU Research Publications

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