Signals that influence T follicular helper cell differentiation and function
Follicular helper T cells have recently emerged as a separate CD4 + T helper lineage specialised in provision of help to B cells. They develop independently from Th1, Th2 and Th17 cells and are critical for humoral immunity, including the generation of long-lived and high affinity plasma cells and memory cells crucial for long-term protection against infections. A stepwise differentiation programme has emerged in which T cell receptor (TCR) signalling strength, CD28-mediated costimulation, B...[Show more]
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|Source:||Seminars in Immunopathology|
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