Signals that influence T follicular helper cell differentiation and function
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Linterman, Michelle; Garcia De Vinuesa, Maria Carola
Description
Follicular helper T cells have recently emerged as a separate CD4 + T helper lineage specialised in provision of help to B cells. They develop independently from Th1, Th2 and Th17 cells and are critical for humoral immunity, including the generation of long-lived and high affinity plasma cells and memory cells crucial for long-term protection against infections. A stepwise differentiation programme has emerged in which T cell receptor (TCR) signalling strength, CD28-mediated costimulation, B...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/64100 |
Source: | Seminars in Immunopathology |
DOI: | 10.1007/s00281-009-0194-z |
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01_Linterman_Signals_that_influence_T_2010.pdf | 469.65 kB | Adobe PDF | Request a copy |
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