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Small heat-shock proteins: important players in regulating cellular proteostasis

Treweek, Teresa; Meehan, Sarah; Ecroyd, Heath; Carver, John


Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection. In doing so, they assist in the maintenance of protein homeostasis (proteostasis) thereby avoiding the deleterious effects that result from loss of protein function and/or protein aggregation. The chaperone properties of sHsps are therefore...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Cellular and Molecular Life Sciences
DOI: 10.1007/s00018-014-1754-5


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