The effect of surface hydrophilicity on the behavior of embryonic cortical neurons
Nisbet, David; Pattanawong, S.; Nunan, J; Shen, W.; Horne, Malcolm K.; Finkelstein, D I; Forsythe, John S.
The aim of this study was to investigate the interaction of mouse embryonic cortical neurons on PLLA and PLGA substrates, which were partially hydrolysed using potassium hydroxide (KOH). The chemical and topographical properties of the surfaces were characterized, and it was discovered that there was a decrease in the hydrophilicity for the PLLA with increasing concentration of KOH. This was due to chemical modifications to the surfaces of the substrates. Alternatively for the PLGA substrate,...[Show more]
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