Skip navigation
Skip navigation
The system will be down for maintenance between 8:00 and 8:15am on Thursday 13, December 2018

Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains

Lee, Vernon; Tay, Joshua K; Chen, Mark; Phoon, M.C.; Xie, M.L.; Wu, Y; Lee, Cynthia; Yap, Jonathan; Sakharkar, K.R.; Sakharkar, M.K.; Lin, Raymond T P; Cui, Lin; Kelly, Paul; Leo, Yee-Sin; Tan, Yee Joo; Chow, Vincent T. K.

Description

Background: In June 2009, we conducted a prospective study in Singapore on 51 individuals to determine their serologic responses before and following receipt of the 2009 Southern Hemisphere seasonal influenza vaccine. Materials and methods: Paired serum samples were obtained before and 3-4 weeks after vaccination. Virus microneutralization assays were performed to quantify antibodies against A/Brisbane/59/2007 vaccine, pandemic H1N1-2009 and A/Puerto Rico/08/34 H1N1 strains. Results:...[Show more]

dc.contributor.authorLee, Vernon
dc.contributor.authorTay, Joshua K
dc.contributor.authorChen, Mark
dc.contributor.authorPhoon, M.C.
dc.contributor.authorXie, M.L.
dc.contributor.authorWu, Y
dc.contributor.authorLee, Cynthia
dc.contributor.authorYap, Jonathan
dc.contributor.authorSakharkar, K.R.
dc.contributor.authorSakharkar, M.K.
dc.contributor.authorLin, Raymond T P
dc.contributor.authorCui, Lin
dc.contributor.authorKelly, Paul
dc.contributor.authorLeo, Yee-Sin
dc.contributor.authorTan, Yee Joo
dc.contributor.authorChow, Vincent T. K.
dc.date.accessioned2015-12-10T23:12:02Z
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/1885/63939
dc.description.abstractBackground: In June 2009, we conducted a prospective study in Singapore on 51 individuals to determine their serologic responses before and following receipt of the 2009 Southern Hemisphere seasonal influenza vaccine. Materials and methods: Paired serum samples were obtained before and 3-4 weeks after vaccination. Virus microneutralization assays were performed to quantify antibodies against A/Brisbane/59/2007 vaccine, pandemic H1N1-2009 and A/Puerto Rico/08/34 H1N1 strains. Results: Post-vaccination, 43%, 12% and 24% of subjects displayed a 4-fold or greater rise in neutralizing antibody titers against the three strains, respectively. There was a positive correlation among individuals who showed increased titers to both pandemic H1N1-2009 and A/Puerto Rico/08/34 (p<0.001). However, this correlation was not observed for A/Brisbane/59/2007 with either strain. The relative conservation and accessibility of predicted B-cell epitopes may explain the limited cross-reactivity of the antibodies directed against common H1N1 epitopes. Conclusions: These results suggest that seasonal influenza vaccination confers a certain degree of cross-protection to other H1N1 strains. The correlation in cross-reactive antibody titers to A/Puerto Rico/08/34 and pandemic H1N1-2009 implies that previous exposure to pre-1957 H1N1 strains may confer some protection against the 2009 pandemic strain.
dc.publisherElsevier
dc.sourceVaccine
dc.subjectKeywords: antibody; epitope; influenza vaccine; adult; antibody response; antibody titer; article; clinical trial; cross reaction; human; Influenza virus A H1N1; male; nucleotide sequence; pandemic influenza; priority journal; prospective study; Puerto Rico; quanti 2009 pandemic; B-cell epitopes; Cross-reactive neutralizing antibodies; Influenza A H1N1; Seasonal influenza vaccine
dc.titleInactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume28
dc.date.issued2010
local.identifier.absfor111706 - Epidemiology
local.identifier.absfor110309 - Infectious Diseases
local.identifier.ariespublicationf2965xPUB866
local.type.statusPublished Version
local.contributor.affiliationLee, Vernon, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTay, Joshua K, Ministry of Defence
local.contributor.affiliationChen, Mark, Tan Tock Seng Hospital Singapore
local.contributor.affiliationPhoon, M.C., National University of Singapore
local.contributor.affiliationXie, M.L., National University of Singapore
local.contributor.affiliationWu, Y, National University of Singapore
local.contributor.affiliationLee, Cynthia, National University of Singapore
local.contributor.affiliationYap, Jonathan, Singapore Ministry of Defence
local.contributor.affiliationSakharkar, K.R., Nanyang Technological University
local.contributor.affiliationSakharkar, M.K., Nanyang Technological University
local.contributor.affiliationLin, Raymond T P, Ministry of Health, Singapore
local.contributor.affiliationCui, Lin, Ministry of Health, Singapore
local.contributor.affiliationKelly, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLeo, Yee-Sin, Ministry of Health, Singapore
local.contributor.affiliationTan, Yee Joo, National University of Singapore
local.contributor.affiliationChow, Vincent T. K., National University of Singapore
local.description.embargo2037-12-31
local.bibliographicCitation.issue42
local.bibliographicCitation.startpage6852
local.bibliographicCitation.lastpage6857
local.identifier.doi10.1016/j.vaccine.2010.08.031
dc.date.updated2016-02-24T08:33:31Z
local.identifier.scopusID2-s2.0-77956886544
local.identifier.thomsonID000283266000006
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Lee_Inactivated_trivalent_seasonal_2010.pdf429.35 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  27 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator