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An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum

Chooi, Yit-Heng; Krill, Christian; Barrow, Russell; Chen, Shasha; Trengove, Robert; Oliver , Richard P; Solomon, Peter


Parastagonospora nodorum is a pathogen of wheat that affects yields globally. Previous transcriptional analysis identified a partially reducing polyketide synthase (PR-PKS) gene, SNOG_00477 (SN477), in P. nodorum that is highly upregulated during infection of wheat leaves. Disruption of the corresponding SN477 gene resulted in the loss of production of two compounds, which we identified as (R)-mellein and (R)-O-methylmellein. Using a Saccharomyces cerevisiae yeast heterologous expression...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Applied and Environmental Microbiology
DOI: 10.1128/AEM.02745-14


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