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Pseudopterosin synthesis from a chiral cross-conjugated hydrocarbon through a series of cycloadditions

Newton, Christopher; Drew, Samuel; Lawrence, Andrew; Willis, Anthony; Paddon-Row, Michael; Sherburn, Michael


The pseudopterosins are a family of diterpene marine natural products, which, by virtue of their interesting anti-inflammatory and analgesic properties, have attracted the attentions of many synthetic chemists. The most efficient syntheses reported to date are 14 and 20 steps in the longest linear sequence for chiral pool and enantioselective approaches, respectively, and all start with precursors that are easily mapped onto the natural product structure. Here, we describe an unconventional...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Nature Chemistry
DOI: 10.1038/nchem.2112


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