Pedroso, Marcelo M; Ely, Fernanda; Mitic, Natasa; Carpenter, Margaret C.; Gahan, Lawrence; Wilcox, Dean E.; Larrabee, James A; Ollis, David; Schenk, Gerhard
Metal ion-dependent, organophosphate-degrading enzymes have acquired increasing attention due to their ability to degrade and thus detoxify commonly used pesticides and nerve agents such as sarin. The best characterized of these enzymes are from Pseudomonas diminuta (OPH) and Agrobacterium radiobacter (OpdA). Despite high sequence homology (>90 % identity) and conserved metal ion coordination these enzymes display considerable variations in substrate specificity, metal ion affinity/preference...[Show more]
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