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Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH)

Pedroso, Marcelo M; Ely, Fernanda; Mitic, Natasa; Carpenter, Margaret C.; Gahan, Lawrence; Wilcox, Dean E.; Larrabee, James A; Ollis, David; Schenk, Gerhard


Metal ion-dependent, organophosphate-degrading enzymes have acquired increasing attention due to their ability to degrade and thus detoxify commonly used pesticides and nerve agents such as sarin. The best characterized of these enzymes are from Pseudomonas diminuta (OPH) and Agrobacterium radiobacter (OpdA). Despite high sequence homology (>90 % identity) and conserved metal ion coordination these enzymes display considerable variations in substrate specificity, metal ion affinity/preference...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Biological Inorganic Chemistry
DOI: 10.1007/s00775-014-1183-9


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