Skip navigation
Skip navigation

Hemin as a generic and potent protein misfolding inhibitor

Liu, Yanqin; Carver, John; Ho, Lam H.; Elias, Abigail K.; Musgrave, Ian F.; Pukala, Tara


Protein misfolding causes serious biological malfunction, resulting in diseases including Alzheimer's disease, Parkinson's disease and cataract. Molecules which inhibit protein misfolding are a promising avenue to explore as therapeutics for the treatment of these diseases. In the present study, thioflavin T fluorescence and transmission electron microscopy experiments demonstrated that hemin prevents amyloid fibril formation of kappa-casein, amyloid beta peptide and α-synuclein by blocking...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2014.10.062


File Description SizeFormat Image
01_Liu_Hemin_as_a_generic_and_potent_2014.pdf1.36 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator