Hemin as a generic and potent protein misfolding inhibitor
Protein misfolding causes serious biological malfunction, resulting in diseases including Alzheimer's disease, Parkinson's disease and cataract. Molecules which inhibit protein misfolding are a promising avenue to explore as therapeutics for the treatment of these diseases. In the present study, thioflavin T fluorescence and transmission electron microscopy experiments demonstrated that hemin prevents amyloid fibril formation of kappa-casein, amyloid beta peptide and α-synuclein by blocking...[Show more]
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|Source:||Biochemical and Biophysical Research Communications|
|01_Liu_Hemin_as_a_generic_and_potent_2014.pdf||1.36 MB||Adobe PDF||Request a copy|
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