Skip navigation
Skip navigation

Mechanisms and energetics of potassium channel block by local anesthetics and antifungal agents

Chen, Rong; Gryn'ova, Ganna; Wu, Yingliang; Coote, Michelle; Chung, Shin-Ho

Description

Many drug molecules inhibit the conduction of several families of cation channels by binding to a small cavity just below the selectivity filter of the channel protein. The exact mechanisms governing drug-channel binding and the subsequent inhibition of conduction are not well understood. Here the inhibition of two K+channel isoforms, Kv1.2 and KCa3.1, by two drug molecules, lidocaine and TRAM-34, is examined in atomic detail using molecular dynamics simulations. A conserved...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/63791
Source: Biochemistry
DOI: 10.1021/bi5009408

Download

File Description SizeFormat Image
01_Chen_Mechanisms_and_energetics_of_2014.pdf2.83 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator