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Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma

Eftekhari, Parivash; Hajizadeh, Sohrab; Reza Raoufy, Mohammad; Reza Masjedi, Mohammad; Yang, Ming; Hansbro, Nicole; Li, Jing Jing; Foster, Paul S


Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in an animal model of steroid resistant acute exacerbation of asthma. Systemically sensitized Balb/C mice were exposed to Ovalbumin aerosol on days 13, 14, 15 and 16, followed by intratracheal...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: EXCLI Journal


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