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The ryanodine receptor store-sensing gate controls Ca 2+ waves and Ca 2+ -triggered arrhythmias

Chen, Wenqian; Wang, Ruiwu; Chen, Biyi; Zhong, Xiaowei; Kong, Huihui; Bai, Yunlong; Zhou, Qiang; Xie, Cuihong; Zhang, Jingqun; Guo, Ang; Tian, Xixi; Jones, Peter P; O'Mara, Megan; Liu, Yingjie; Mi, Tao; Zhang, Lin; Bolstad, Jeff; Semeniuk, Lisa; Cheng, Hongqiang; Zhang, Jianlin; Chen, Ju; Tieleman, D. Peter; Gillis, Anne M; Duff, Henry J; Fill, Michael; Song, Long-Sheng; Chen, S R Wayne


Spontaneous Ca 2+ release from intracellular stores is important for various physiological and pathological processes. In cardiac muscle cells, spontaneous store overload-induced Ca 2+ release (SOICR) can result in Ca 2+ waves, a major cause of ventricular tachyarrhythmias (VTs) and sudden death. The molecular mechanism underlying SOICR has been a mystery for decades. Here we show that a point mutation, E4872A, in the helix bundle crossing region (the proposed gate) of the cardiac ryanodine...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Nature Medicine
DOI: 10.1038/nm.3440


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