Bohman, Bjorn; Nordlander, G.; Nordenhem, H.; Sunnerheim, K.; Borg-Karlson, A.-K.; Unelius, C.R.
Ethyl cinnamate has been isolated from the bark of Pinus contorta in the search for antifeedants for the pine weevil, Hylobius abietis. Based on this lead compound, a number of structurally related compounds were synthesized and tested. The usability of the Topliss scheme, a flow diagram previously used in numerous structure-activity relationship (SAR) studies, was evaluated in an attempt to find the most potent antifeedants. The scheme was initially followed stepwise; subsequently, all...[Show more]
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