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Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation

Carr, Paul D; Ewans, Cameron; Dai, Jin; Ollis, David; Murphy, James M; Jackson, Colin; Young, I M


Interleukin-3 (IL-3) is a cytokine secreted by mast cells and activated T-cells known to be an important regulator of differentiation, survival, proliferation and activation of a range of haemopoietic lineages. The effects of IL-3 on target cells are mediated by a transmembrane receptor system composed of a cytokine-specific α-subunit and a β-subunit, the principal signalling entity. In the mouse, two β-subunits have co-evolved: a common β-subunit (βc) shared between IL-3 and the related...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Biochemical Journal
DOI: 10.1042/BJ20140863


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