Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Brooks, Andrew; Dai, Wen; O'Mara, Megan; Abankwa, Daniel; Chhabra, Yash; Pelekanos, Rebecca; Gardon, Olivier; Tunny, Kathryn; Blucher, Kristopher; Morton, Craig; Parker, Michael William; Sierecki, Emma; Gambin, Yann; Gomez, Guillermo A.; Alexandrov, Kirill; Wilson, Ian A; Doxastakis, Manolis; Mark, Alan E.; Waters, Michael J.
Signaling from JAK (Janus kinase) protein kinases to STAT (signal transducers and activators of transcription) transcription factors is key to many aspects of biology and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic. We present a complete mechanistic model for activation of receptor-bound JAK2, based on an archetypal cytokine receptor, the growth hormone receptor. For this, we used fluorescence resonance energy transfer to monitor positioning of the...[Show more]
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