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High-risk prescribing and incidence of frailty among older community-dwelling men

Gnjidic, Donijela; Hilmer, Sarah; Blyth, Fiona; Naganathan, Vasin; Cumming, Robert; Handelsman, D; McLachlan, Andrew; Abernethy, D; Banks, Emily; Le Couteur, D


Evidence about the association between treatment with high-risk medicines and frailty in older individuals is limited. We investigated the relationship between high-risk prescribing and frailty at baseline, as well as 2-year incident frailty, in 1,662 men 70 years of age. High-risk prescribing was defined as polypharmacy (5 medicines), hyperpolypharmacy (10 medicines), and by the Drug Burden Index (DBI), a dose-normalized measure of anticholinergic and sedative medicines. At baseline, frail...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Clinical Pharmacology and Therapeutics
DOI: 10.1038/clpt.2011.258


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