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Myelopoiesis related to perinatal spleen

Hinton, Rebecca; Petvises, Sawang; O'Neill, Helen


Adult murine spleen is known to have a major role in the development of dendritic cell (DC) subsets, including conventional DC and plasmacytoid DC. In this lab, long-term cultures (LTCs) established from murine spleen support continuous production of novel dendritic-like cells, termed LTC-DC. An in vivo equivalent subset also exists in spleen, namely L-DC. As co-cultures using LTC-derived splenic stroma support the outgrowth of L-DC from spleen and bone marrow sources, it is likely that spleen...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/icb.2010.156


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