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Alternatively activated macrophage possess antitumor cytotoxicity that is induced by il-4 and mediated by arginase-1

Ellyard, Julia; Quah, Ben; Simson, Ljubov; Parish, Christopher


Earlier studies have shown that the adoptive transfer of Th2-polarized CD4+ T cells can clear established tumors from mice in an antigen-specific manner. Although eosinophils were implicated in this process, the exact mechanism of tumor clearance and which immune effector cells were involved, remain to be defined. Consequently, experiments were undertaken to elucidate the mechanism of Th2-mediated destruction of B16-F1 melanoma cells by examining the in vitro antitumor activity of leukocytes...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Immunotherapy
DOI: 10.1097/CJI.0b013e3181cd8746


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