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The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI

Chen, Wan-Na; Loscha, Karin; Nitsche, Christoph; Graham, Bim; Otting, Gottfried


The C-terminal β-hairpin of NS2B (NS2Bc) in the dengue virus NS2B-NS3 protease is required for full enzymatic activity. In crystal structures without inhibitor and in the complex with bovine pancreatic trypsin inhibitor (BPTI), NS2Bc is displaced from th

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: FEBS Letters
DOI: 10.1016/j.febslet.2014.05.018
Access Rights: Open Access


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