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Methionine Oxidation Enhances κ-Casein Amyloid Fibril Formation

Koudelka, Tomas; Dehle, Francis C.; Musgrave, Ian F.; Hoffmann, Peter; Carver, John


The effects of protein oxidation, for example of methionine residues, are linked to many diseases, including those of protein misfolding, such as Alzheimer's disease. Protein misfolding diseases are characterized by the accumulation of insoluble proteinaceous aggregates comprised mainly of amyloid fibrils. Amyloid-containing bodies known as corpora amylacea (CA) are also found in mammary secretory tissue, where their presence slows milk flow. The major milk protein κ-casein readily forms...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Agricultural and Food Chemistry
DOI: 10.1021/jf205168t


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