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Ion Mobility Mass Spectrometry Studies of the Inhibition of Alpha Synuclein Amyloid Fibril Formation by (−)-Epigallocatechin-3-Gallate

Liu, Yanqin; Ho, Lam H.; Carver, John; Pukala, Tara


Ion mobility-mass spectrometry (IM-MS) is emerging as an important biophysical technique for the structural analysis of proteins and their assemblies, in particular for structurally heterogeneous systems such as those on the protein misfolding and aggregation pathway. Using IM-MS we have monitored amyloid fibril formation of A53T α-synuclein, a mutant synuclein protein associated with Parkinson's disease, and identified that a conformational change towards a more compact structure occurs during...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH10334


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