Stranks, Samuel; Ecroyd, Heath; Van Sluyter, Steven; Waters, Elizabeth; Carver, John; von Smekal, Lorenz
The amorphous aggregation of proteins is associated with many phenomena, ranging from the formation of protein wine haze to the development of cataract in the eye lens and the precipitation of recombinant proteins during their expression and purification. While much literature exists describing models for linear protein aggregation, such as amyloid fibril formation, there are few reports of models which address amorphous aggregation. Here, we propose a model to describe the amorphous...[Show more]
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