Control systems and decision making for antibody production
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Goodnow, Christopher; Garcia De Vinuesa, Maria Carola; Randall, Katrina; Mackay, Fabienne; Brink, Robert
Description
This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/63178 |
Source: | Nature Immunology |
DOI: | 10.1038/ni.1900 |
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01_Goodnow_Control_systems_and_decision_2010.pdf | 489.56 kB | Adobe PDF | Request a copy |
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