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Control systems and decision making for antibody production

Goodnow, Christopher; Garcia De Vinuesa, Maria Carola; Randall, Katrina; Mackay, Fabienne; Brink, Robert


This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Nature Immunology
DOI: 10.1038/ni.1900


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