Deane, Karen; Summers, Robert; Lehane, Adele; Martin, Rowena; Barrow, Russell
The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutations in the parasite's CQ resistance transporter (PfCRT) confer resistance to CQ by enabling the protein to transport the drug away from its site of action, and it is thought that resistance-reversers such as CP exert...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.