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Interaction of embryonic cortical neurons on nanofibrous scaffolds for neural tissue engineering

Nisbet, David; Pattanawong, S.; Ritchie, N. E; Shen, W; Finkelstein, David; Horne, Malcolm K; Forsythe, John S.


The interaction of murine embryonic cortical neurons on randomly orientated electrospun scaffolds of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) is investigated in this study. The scaffolds were surface treated with different concentrations of KOH to partially hydrolyze the surface and therefore change the surface tension. Hydrophilicity did not significantly influence the number of primary and secondary branches; however, it had a considerable effect on neurite extension. For...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Neural Engineering
DOI: 10.1088/1741-2560/4/2/004


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