Amyloid Fibril Formation by Bovine Milk α s2 -Casein Occurs under Physiological Conditions Yet Is Prevented by Its Natural Counterpart, α s1 -Casein
The calcified proteinaceous deposits, or corpora amylacea, of bovine mammary tissue often comprise a network of amyloid fibrils, the origins of which have not been fully elucidated. Here, we demonstrate by transmission electron microscopy, dye binding assays, and X-ray fiber diffraction that bovine milk αs2-casein, a protein synthesized and secreted by mammary epithelial cells, readily forms fibrils in vitro. As a component of whole αs-casein, αs2-casein was separated from αs1-casein under...[Show more]
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