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The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation

Ecroyd, Heath; Carver, John

Description

Protein aggregation can proceed via disordered or ordered mechanisms, with the latter being associated with amyloid fibril formation, which has been linked to a number of debilitating conditions including Alzheimer's, Parkinson's and Creutzfeldt-Jakob diseases. Small heat-shock proteins (sHsps), such as αB-crystallin, act as chaperones to prevent protein aggregation and are thought to play a key role in the prevention of protein-misfolding diseases. In this study, we have explored the potential...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/63132
Source: The FEBS Journal
DOI: 10.1111/j.1742-4658.2008.06257.x

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