The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation
Protein aggregation can proceed via disordered or ordered mechanisms, with the latter being associated with amyloid fibril formation, which has been linked to a number of debilitating conditions including Alzheimer's, Parkinson's and Creutzfeldt-Jakob diseases. Small heat-shock proteins (sHsps), such as αB-crystallin, act as chaperones to prevent protein aggregation and are thought to play a key role in the prevention of protein-misfolding diseases. In this study, we have explored the potential...[Show more]
|Collections||ANU Research Publications|
|Source:||The FEBS Journal|
|01_Ecroyd_The_effect_of_small_molecules_2008.pdf||638.76 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.