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Enhancing neurite outgrowth from primary neurones and neural stem cells using thermoresponsive hydrogel scaffolds for the repair of spinal cord injury

Nisbet, David; Moses, D.; Gengenbach, Thomas; Forsythe, John S.; Finkelstein, David; Horne, Malcolm K


In this study, thermoresponsive xyloglucan hydrogel scaffolds were investigated as candidates for neural tissue engineering of the spinal cord. The hydrogels were optimized to provide similar mechanical properties to that of native spinal cord, although also being function-alized through the immobilization of poly-D-lysine to promote neurone adhesion and neurite outgrowth. Under 2D and 3D culture conditions, xyloglucan scaffolds supported the differentiation of primary cortical neurones....[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Biomedical Materials Research. Part A
DOI: 10.1002/jbm.a.31962


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