Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1
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Indurthi, Dinesh C; Pera, Elena; Kim, Hye-Lim; Chu, Cindy P-Y; McLeod, Malcolm; McIntosh, J. Michael; Absalom, Nathan; Chebib, Mary
Description
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in fast synaptic transmission. nAChRs are pentameric receptors formed from a combination of different or similar subunits to produce heteromeric or homomeric channels. The heteromeric, α9α10 nAChR subtype is well-known for its role in the auditory system, being expressed in cochlear hair cells. These nAChRs have also been shown to be involved in immune-modulation. Antagonists of α9α10 nAChRs, like the α-conotoxin...[Show more]
Collections | ANU Research Publications |
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Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/63028 |
Source: | Biochemical Pharmacology |
DOI: | 10.1016/j.bcp.2014.02.002 |
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01_Indurthi_Presence_of_multiple_binding_2014.pdf | 1.33 MB | Adobe PDF | Request a copy |
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