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Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1

Indurthi, Dinesh C; Pera, Elena; Kim, Hye-Lim; Chu, Cindy P-Y; McLeod, Malcolm; McIntosh, J. Michael; Absalom, Nathan; Chebib, Mary


Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in fast synaptic transmission. nAChRs are pentameric receptors formed from a combination of different or similar subunits to produce heteromeric or homomeric channels. The heteromeric, α9α10 nAChR subtype is well-known for its role in the auditory system, being expressed in cochlear hair cells. These nAChRs have also been shown to be involved in immune-modulation. Antagonists of α9α10 nAChRs, like the α-conotoxin...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Biochemical Pharmacology
DOI: 10.1016/j.bcp.2014.02.002


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