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IFN-gamma regulates murine interferon-inducible T cell alpha chemokine (I-TAC) expression in dendritic cell lines and during experimental autoimmune encephalomyelitis (EAE)

Hamilton, Nicholas H R; Banyer, Joanne; Hapel, Andrew; Mahalingam, Surendran; Ramsay, Alistair; Ramshaw, Ian; Thomson, Scott


Murine interferon-inducible T cell alpha chemokine (I-TAC) is a potent non-ELR Cys-X-Cys (CXC) chemokine that predominantly attracts activated T lymphocytes and binds to the receptor CXCR3. Using semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) we analysed murine I-TAC expression in two different progenitor dendritic cell (DC) lines, MTHC-D2 and JAWS II which were exposed to various cytokines, and Con A-activated splenocytes from a panel of knockout mice. Analysis of...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Scandinavian Journal of Immunology
DOI: 10.1046/j.0300-9475.2001.01019.x


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