Shelden, Megan; Howitt, Susan; Price, Graeme (Dean)
We have completed the first comprehensive transmembrane topology determination for a member of the ubiquitous and important SulP/SLC26 family of coupled anion transporters found in eukaryotes and prokaryotes. The prokaryotic member that we have mapped, namely BicA from Synechococcus PCC7002, is an important Na+-dependent bicarbonate transporter that is likely to play a major role in global primary productivity via the CO2 concentrating mechanism in cyanobacteria. We experimentally determined...[Show more]
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