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Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-b1 and TGF-b3

Adams, Damian H; Ruzehaji, N; Strudwick, Xanthe L; Greenwood, J E; Campbell, Hugh; Arkell, Ruth; Cowin, Allison


Background The pathophysiological mechanisms involved in burn injury repair are still not fully understood but include processes involving cellular proliferation, migration and adhesion. The actin cytoskeleton is intricately involved in these key wound repair processes. Flightless I (Flii), an actin-remodelling protein and transcriptional regulator, is an important regulator of wound healing. Objectives To investigate the function of Flii gene expression in burn injury repair. Methods...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: British Journal of Dermatology
DOI: 10.1111/j.1365-2133.2009.09296.x


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