Shishmarev, Dmitry; Wang, Yao; Mason, Claire E; Su, Xun-Cheng; Oakley, Aaron; Graham, Bim; Huber, Thomas; Dixon, Nicholas Edward; Otting, Gottfried
Single-stranded DNA (ssDNA) binding protein (SSB) is an essential protein to protect ssDNA and recruit specific ssDNA-processing proteins. Escherichia coli SSB forms a tetramer at neutral pH, comprising a structurally well-defined ssDNA binding domain (OB-domain) and a disordered C-terminal domain (C-domain) of ∼64 amino acid residues. The C-terminal eight-residue segment of SSB (C-peptide) has been shown to interact with the OB-domain, but crystal structures failed to reveal any electron...[Show more]
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