Know your enemy: Understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics
The prevention and treatment of malaria is heavily dependent on antimalarial drugs. However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium falciparum parasites 50 years ago, efforts to control the disease have been thwarted by failed or failing drugs. Mutations in the parasite's 'chloroquine resistance transporter' (PfCRT) are the primary cause of CQ resistance. Furthermore, changes in PfCRT (and in several other transport proteins) are associated with decreases or...[Show more]
|Collections||ANU Research Publications|
|Source:||Cellular and Molecular Life Sciences|
|01_Summers_Know_your_enemy:_Understanding_2012.pdf||1.06 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.