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Know your enemy: Understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

Summers, Robert; Nash, Megan; Martin, Rowena


The prevention and treatment of malaria is heavily dependent on antimalarial drugs. However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium falciparum parasites 50 years ago, efforts to control the disease have been thwarted by failed or failing drugs. Mutations in the parasite's 'chloroquine resistance transporter' (PfCRT) are the primary cause of CQ resistance. Furthermore, changes in PfCRT (and in several other transport proteins) are associated with decreases or...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Cellular and Molecular Life Sciences
DOI: 10.1007/s00018-011-0906-0


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