IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophages
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Li, Yan; Ohms, Stephen J; Shannon, M Frances; Sun, Chao; Fan, Jun
Description
DNA demethylation has been found to occur at the promoters of a number of actively expressed cytokines and is believed to play a critical role in transcriptional regulation. While many DNA demethylation studies have focused on T cell activation, proliferation and differentiation, changes in DNA methylation in other types of immune cells are less well studied. We found that the expression of two cytokines (IL-2 and GM-CSF) responded differently to activation in three types of immune cells: EL4,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/62796 |
Source: | Biochemical and Biophysical Research Communications |
DOI: | 10.1016/j.bbrc.2012.02.094 |
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01_Li_IL-2_and_GM-CSF_are_regulated_2012.pdf | 570.02 kB | Adobe PDF | Request a copy |
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