IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophages
Li, Yan; Ohms, Stephen J; Shannon, M Frances; Sun, Chao; Fan, Jun
DNA demethylation has been found to occur at the promoters of a number of actively expressed cytokines and is believed to play a critical role in transcriptional regulation. While many DNA demethylation studies have focused on T cell activation, proliferation and differentiation, changes in DNA methylation in other types of immune cells are less well studied. We found that the expression of two cytokines (IL-2 and GM-CSF) responded differently to activation in three types of immune cells: EL4,...[Show more]
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