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Brain plasticity, memory and neurological disorders: an epigenetic perspective

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Lockett, Gabrielle; Wilkes (previously Baglow), Fiona; Maleszka, Ryszard

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Epigenomic settings control gene regulation in both developing and postmitotic tissue, whereas abnormal regulation of epigenomic settings has been implicated in many developmental and neurological disorders. Evidence is emerging for the roles of epigenetic mechanisms in the mature nervous system, in the dynamic processes of learning and memory. The discovery of the involvement of DNA methylation and histone acetylation and methylation in neuronal processing provides a possible answer to the...[Show more]

dc.contributor.authorLockett, Gabrielle
dc.contributor.authorWilkes (previously Baglow), Fiona
dc.contributor.authorMaleszka, Ryszard
dc.date.accessioned2015-12-10T23:06:00Z
dc.identifier.issn0959-4965
dc.identifier.urihttp://hdl.handle.net/1885/62593
dc.description.abstractEpigenomic settings control gene regulation in both developing and postmitotic tissue, whereas abnormal regulation of epigenomic settings has been implicated in many developmental and neurological disorders. Evidence is emerging for the roles of epigenetic mechanisms in the mature nervous system, in the dynamic processes of learning and memory. The discovery of the involvement of DNA methylation and histone acetylation and methylation in neuronal processing provides a possible answer to the long-standing riddle of how memories persist in a biological system whose cellular composition is in a constant state of flux and renewal. This mini review focuses on present research in DNA methylation and histone posttranslational modifications in learning and memory, age-related cognitive decline, and related pathological disorders.
dc.publisherLippincott Williams & Wilkins
dc.sourceNeuroReport
dc.subjectKeywords: histone; acetylation; Alzheimer disease; amyotrophic lateral sclerosis; cognitive defect; DNA methylation; epigenetics; fragile X syndrome; Friedreich ataxia; genetic disorder; human; Huntington chorea; learning; memory; nerve cell plasticity; nervous sys ageing; DNA methylation; histone modification; honey bee; learning; memory; neurodegeneration; neurological disorders
dc.titleBrain plasticity, memory and neurological disorders: an epigenetic perspective
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume21
dc.date.issued2010
local.identifier.absfor060410 - Neurogenetics
local.identifier.absfor060404 - Epigenetics (incl. Genome Methylation and Epigenomics)
local.identifier.ariespublicationu9511635xPUB714
local.type.statusPublished Version
local.contributor.affiliationLockett, Gabrielle, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWilkes (previously Baglow), Fiona, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMaleszka, Ryszard, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue14
local.bibliographicCitation.startpage909
local.bibliographicCitation.lastpage913
local.identifier.doi10.1097/WNR.0b013e32833e9288
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
dc.date.updated2016-02-24T12:08:01Z
local.identifier.scopusID2-s2.0-77956398534
CollectionsANU Research Publications

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