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Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors

Wong, Ma-Li; Dong, C.; Andreev, V P; Arcos-Burgos, Mauricio (Oscar); Licinio, Julio

Description

Major depressive disorder (MDD) is the most common psychiatric disorder and the second overall cause of disability. Even though a significant amount of the variance in the MDD phenotype is explained by inheritance, specific genetic variants conferring susceptibility to MDD explain only a minimal proportion of MDD causality. Moreover, genome-wide association studies have only identified two small-sized effect loci that reach genome-wide significance. In this study, a group of Mexican-American...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/62418
Source: Molecular Psychiatry
DOI: 10.1038/mp.2012.13

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