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Protein Structure Determination Using a Combination of Cross-Linking, Mass Spectrometry, and Molecular Modeling

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Mouradov, Dmitri; King, Gordon J.; Ross, Ian R.; Forwood, Jade; Hume, D A; Sinz, Andrea; Martin, Jennifer Louise; Kobe, Bostjan; Huber, Thomas

Description

Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.

dc.contributor.authorMouradov, Dmitri
dc.contributor.authorKing, Gordon J.
dc.contributor.authorRoss, Ian R.
dc.contributor.authorForwood, Jade
dc.contributor.authorHume, D A
dc.contributor.authorSinz, Andrea
dc.contributor.authorMartin, Jennifer Louise
dc.contributor.authorKobe, Bostjan
dc.contributor.authorHuber, Thomas
dc.date.accessioned2015-12-10T23:04:20Z
dc.identifier.isbn9781588298096
dc.identifier.urihttp://hdl.handle.net/1885/62322
dc.description.abstractCross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
dc.publisherHumana Press Inc.
dc.relation.ispartofStructural Proteomics: High Throughput Methods
dc.relation.isversionof1st Edition
dc.subjectKeywords: 3,3' dithiobis(sulfosuccinimidyl propionate); 3,3'-dithiobis(sulfosuccinimidyl propionate); carboxypeptidase A; cross linking reagent; CTE 1 protein, mouse; CTE-1 protein, mouse; succinimide derivative; thiol ester hydrolase; animal; article; chemical str
dc.titleProtein Structure Determination Using a Combination of Cross-Linking, Mass Spectrometry, and Molecular Modeling
dc.typeBook chapter
local.description.notesImported from ARIES
dc.date.issued2008
local.identifier.absfor030406 - Proteins and Peptides
local.identifier.ariespublicationU4217927xPUB687
local.type.statusPublished Version
local.contributor.affiliationMouradov, Dmitri, University of Queensland
local.contributor.affiliationKing, Gordon J., University of Queensland
local.contributor.affiliationRoss, Ian R., University of Queensland
local.contributor.affiliationForwood, Jade, University of Queensland
local.contributor.affiliationHume, D A, University of Queensland
local.contributor.affiliationSinz, Andrea, University of Leipzig
local.contributor.affiliationMartin, Jennifer Louise, University of Queensland
local.contributor.affiliationKobe, Bostjan, University of Queensland
local.contributor.affiliationHuber, Thomas, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage459
local.bibliographicCitation.lastpage477
dc.date.updated2015-12-10T08:43:55Z
local.bibliographicCitation.placeofpublicationTotowa, NJ, USA
local.identifier.scopusID2-s2.0-49649097784
CollectionsANU Research Publications

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