Protein Structure Determination Using a Combination of Cross-Linking, Mass Spectrometry, and Molecular Modeling
Mouradov, Dmitri; King, Gordon J.; Ross, Ian R.; Forwood, Jade; Hume, D A; Sinz, Andrea; Martin, Jennifer Louise; Kobe, Bostjan; Huber, Thomas
Description
Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
Collections | ANU Research Publications |
---|---|
Date published: | 2008 |
Type: | Book chapter |
URI: | http://hdl.handle.net/1885/62322 |
Book Title: | Structural Proteomics: High Throughput Methods |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Mouradov_Protein_Structure_2008.pdf | 1.23 MB | Adobe PDF | Request a copy | |
02_Mouradov_Protein_Structure_2008.pdf | 1.24 MB | Adobe PDF | Request a copy | |
03_Mouradov_Protein_Structure_2008.pdf | 5.06 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator