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Protein Structure Determination Using a Combination of Cross-Linking, Mass Spectrometry, and Molecular Modeling

Mouradov, Dmitri; King, Gordon J.; Ross, Ian R.; Forwood, Jade; Hume, D A; Sinz, Andrea; Martin, Jennifer Louise; Kobe, Bostjan; Huber, Thomas

Description

Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.

CollectionsANU Research Publications
Date published: 2008
Type: Book chapter
URI: http://hdl.handle.net/1885/62322

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