Skip navigation
Skip navigation
A change is coming. Click to see a sneak peek of the new Open Research Repository.

Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)

Request a Copy

link to publisher version

  • Altmetric Citations

Sudta, Pichit; Kirk, Nicholas; Bezos, Anna; Gurlica, Anthony; Mitchell, Rhys; Weber, Thomas; Willis, Anthony; Prabpai, Samran; Kongsaeree, Palangpon; Suksamrarn, Sunit; Kelso, Michael; Parish, Christopher

Description

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416

dc.contributor.authorSudta, Pichit
dc.contributor.authorKirk, Nicholas
dc.contributor.authorBezos, Anna
dc.contributor.authorGurlica, Anthony
dc.contributor.authorMitchell, Rhys
dc.contributor.authorWeber, Thomas
dc.contributor.authorWillis, Anthony
dc.contributor.authorPrabpai, Samran
dc.contributor.authorKongsaeree, Palangpon
dc.contributor.authorSuksamrarn, Sunit
dc.contributor.authorKelso, Michael
dc.contributor.authorParish, Christopher
dc.date.accessioned2015-12-10T23:04:20Z
dc.identifier.issn0004-9425
dc.identifier.urihttp://hdl.handle.net/1885/62321
dc.description.abstractThe indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416
dc.publisherCSIRO Publishing
dc.sourceAustralian Journal of Chemistry
dc.subjectKeywords: Angiogenesis inhibitors; Anti-angiogenic activity; Anticancer drug; Fused-ring system; In-vitro models; Intra-molecular hydrogen bonds; Structural characteristics; Structural motifs; Scaffolds; Hydrocarbons
dc.titleSynthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume66
dc.date.issued2013
local.identifier.absfor030606 - Structural Chemistry and Spectroscopy
local.identifier.ariespublicationu4005981xPUB687
local.type.statusPublished Version
local.contributor.affiliationSudta, Pichit, Srinakharinwirot University
local.contributor.affiliationKirk, Nicholas, University of Wollongong
local.contributor.affiliationBezos, Anna, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGurlica, Anthony, University of Wollongong
local.contributor.affiliationMitchell, Rhys, University of Wollongong
local.contributor.affiliationWeber, Thomas, University of Wollongong
local.contributor.affiliationWillis, Anthony, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationPrabpai, Samran, Mahidol University
local.contributor.affiliationKongsaeree, Palangpon, Mahidol University
local.contributor.affiliationParish, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSuksamrarn, Sunit, Srinakharinwirot University
local.contributor.affiliationKelso, Michael, University of Wollongong
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage864
local.bibliographicCitation.lastpage873
local.identifier.doi10.1071/CH13219
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2016-02-24T10:25:49Z
local.identifier.scopusID2-s2.0-84882683064
local.identifier.thomsonID000323176800005
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Sudta_Synthesis,_structural_2013.pdf653.3 kBAdobe PDF    Request a copy
Show simple item record


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator