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Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)

Sudta, Pichit; Kirk, Nicholas; Bezos, Anna; Gurlica, Anthony; Mitchell, Rhys; Weber, Thomas; Willis, Anthony; Prabpai, Samran; Kongsaeree, Palangpon; Suksamrarn, Sunit; Kelso, Michael; Parish, Christopher

Description

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/62321
Source: Australian Journal of Chemistry
DOI: 10.1071/CH13219

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