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A General Target Selection Method for Crystallographic Proteomics

Robin, Gautier; Cowieson, Nathan; Guncar, G; Forwood, Jade; Listwan, Pawel; Hume, D A; Kobe, Bostjan; Martin, Jennifer Louise; Huber, Thomas

Description

Increasing the success in obtaining structures and maximizing the value of the structures determined are the two major goals of target selection in structural proteomics. This chapter presents an efficient and flexible target selection procedure supplemented with a Web-based resource that is suitable for small- to large-scale structural genomics projects that use crystallography as the major means of structure determination. Based on three criteria, biological significance, structural novelty,...[Show more]

dc.contributor.authorRobin, Gautier
dc.contributor.authorCowieson, Nathan
dc.contributor.authorGuncar, G
dc.contributor.authorForwood, Jade
dc.contributor.authorListwan, Pawel
dc.contributor.authorHume, D A
dc.contributor.authorKobe, Bostjan
dc.contributor.authorMartin, Jennifer Louise
dc.contributor.authorHuber, Thomas
dc.date.accessioned2015-12-10T23:04:18Z
dc.identifier.isbn9781588298096
dc.identifier.urihttp://hdl.handle.net/1885/62312
dc.description.abstractIncreasing the success in obtaining structures and maximizing the value of the structures determined are the two major goals of target selection in structural proteomics. This chapter presents an efficient and flexible target selection procedure supplemented with a Web-based resource that is suitable for small- to large-scale structural genomics projects that use crystallography as the major means of structure determination. Based on three criteria, biological significance, structural novelty, and "crystallizability," the approach first removes (filters) targets that do not meet minimal criteria and then ranks the remaining targets based on their "crystallizability" estimates. This novel procedure was designed to maximize selection efficiency, and its prevailing criteria categories make it suitable for a broad range of structural proteomics projects.
dc.publisherHumana Press Inc.
dc.relation.ispartofStructural Proteomics: High Throughput Methods
dc.relation.isversionof1st Edition
dc.subjectKeywords: protein; animal; article; chemistry; crystallization; human; methodology; protein database; structural homology; X ray crystallography; Animals; Crystallization; Crystallography, X-Ray; Databases, Protein; Humans; Proteins; Structural Homology, Protein
dc.titleA General Target Selection Method for Crystallographic Proteomics
dc.typeBook chapter
local.description.notesImported from ARIES
dc.date.issued2008
local.identifier.absfor030406 - Proteins and Peptides
local.identifier.ariespublicationU4217927xPUB686
local.type.statusPublished Version
local.contributor.affiliationRobin, Gautier, University of Queensland
local.contributor.affiliationCowieson, Nathan, University of Queensland
local.contributor.affiliationGuncar, G, University of Queensland
local.contributor.affiliationForwood, Jade, University of Queensland
local.contributor.affiliationListwan, Pawel, University of Queensland
local.contributor.affiliationHume, D A, University of Queensland
local.contributor.affiliationKobe, Bostjan, University of Queensland
local.contributor.affiliationMartin, Jennifer Louise, University of Queensland
local.contributor.affiliationHuber, Thomas, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage27
local.bibliographicCitation.lastpage37
dc.date.updated2015-12-10T08:43:42Z
local.bibliographicCitation.placeofpublicationTotowa, NJ, USA
local.identifier.scopusID2-s2.0-49649115755
CollectionsANU Research Publications

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