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Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes

Wong, Emily; Sanderson, Claire; Deakin, Janine; Whittington, Camilla M; Papenfuss, Anthony T; Belov, Katherine


Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily, situated in the leukocyte receptor complex (LRC) and the C-type lectin superfamily, located in the natural killer complex (NKC). Here, we describe the largest NK receptor gene expansion seen to date. We identified 213 putative C-type lectin NK receptor homologs in the genome of the platypus. Many have arisen as the result of a lineage-specific expansion....[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Immunogenetics
DOI: 10.1007/s00251-009-0386-7


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