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A radish seed antifungal peptide with a high amyloid fibril-forming propensity

Garvey, Megan; Meehan, Sarah; Gras, Sally L.; Schirra, Horst J.; Craik, David J; Van der Weerden, Nicole L.; Anderson, Marilyn; Gerrard, Juliet A.; Carver, John


The amyloid fibril-forming ability of two closely related antifungal and antimicrobial peptides derived from plant defensin proteins has been investigated. As assessed by sequence analysis, thioflavin T binding, transmission electron microscopy, atomic force microscopy and X-ray fiber diffraction, a 19 amino acid fragment from the C-terminal region of Raphanus sativus antifungal protein, known as RsAFP-19, is highly amyloidogenic. Further, its fibrillar morphology can be altered by externally...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Biochimica et Biophysica Acta: Proteins & Proteomics
DOI: 10.1016/j.bbapap.2013.04.030


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