Garvey, Megan; Meehan, Sarah; Gras, Sally L.; Schirra, Horst J.; Craik, David J; Van der Weerden, Nicole L.; Anderson, Marilyn; Gerrard, Juliet A.; Carver, John
The amyloid fibril-forming ability of two closely related antifungal and antimicrobial peptides derived from plant defensin proteins has been investigated. As assessed by sequence analysis, thioflavin T binding, transmission electron microscopy, atomic force microscopy and X-ray fiber diffraction, a 19 amino acid fragment from the C-terminal region of Raphanus sativus antifungal protein, known as RsAFP-19, is highly amyloidogenic. Further, its fibrillar morphology can be altered by externally...[Show more]
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