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Saquinavir Inhibits the malaria parasite's chloroquine resistance transporter

Martin, Rowena; Butterworth, Alice S.; Gardiner, Donald L.; Kirk, Kiaran; McCarthy, James S.; Skinner-Adams, Tina S.


The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at clinically relevant concentrations. Moreover, it has been reported that these APIs potentiate the activity of chloroquine (CQ) against this parasite in vitro. The mechanism underlying this effect is not understood, but the degree of chemosensitization varies between the different APIs and, with the exception of ritonavir, appears to be...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Antimicrobial Agents and Chemotherapy
DOI: 10.1128/AAC.00166-12
Access Rights: Open Access


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