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Multiple functions of yeast mitochondrial transcription factor Mtf1p during initiation

Savkina, Maria; Temiakov, Dmitry; McAllister, William T; Anikin, Michael


Transcription of the yeast mitochondrial genome is carried out by an RNA polymerase (Rpo41p) that is related to single subunit bacteriophage RNA polymerases but requires an additional factor (Mtf1p) for initiation. In this work we show that Mtf1p is involved in multiple roles during initiation including discrimination of upstream base pairs in the promoter, initial melting of three to four base pairs around the site of transcript initiation, and suppression of nonspecific initiation. It, thus,...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M109.051003


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